Michael Koval Lab - Emory School of Medicine

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Koval Lab - Complete Reference List

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Research Articles

Chihade, D. B., P. Smith, D. A. Swift, S. Otani, W. Zhang, C.-W. Chen, L. A. Jeffers, Z. Liang, E. M. Burd, A. B. Farris, B. S. Statieh, D. M. Guidot, M. L. Ford, M. Koval, C. M. Coopersmith. 2023. Myosin light chain kinase deletion worsens lung permeability and increases mortality in pneumonia-induced sepsis, Shock, in press. (PubMed)

Bose, A., G. Kasle, R. Jana, M. Maulik, D. Thomas, V. Mulchandani, P. Mukherjee, M. Koval and J. Das Sarma. 2023. Regulatory role of endoplasmic reticulum resident chaperone protein ERp29 in anti-murine ?-coronavirus host cell response. J. Biol. Chem., 299:102836. (PubMed)

Dunaway, L. M. Billaud, E. Macal, M. Good, C. Medina, U. Lorenz, K. Ravichandran, M. Koval, and B. E. Isakson. 2023. Amount of Pannexin 1 in smooth muscle cells regulates sympathetic nerve induced vasoconstriction. Hypertension. 80:416-425. (PubMed)

Roe, M. K., M. A. Perez, H.-M. Hsiao, S. A. Lapp, H.-Y. Sun, S. Jadhao, A. R. Young, Y. S. Batista, R. C. Reed, A. Taz, A. Piantadosi, X. Chen, B. Liang, M. Koval, T. A. Snider, M. L. Moore, E. J. Anderson, L. J. Anderson, C. C. Stobart, and C. A. Rostad. 2023. An RSV live-attenuated vaccine candidate lacking G protein mucin domains is attenuated, immunogenic, and effective in preventing RSV in BALB/c mice. J. Infect. Dis., 227: 50-60. (PubMed)

Lyons, J. D., P. Mandal, S. Otani, D. B. Chihade, K. F. Easley, D. A. Swift, E. M. Burd, Z. Liang, M. Koval, E. S. Mocarski, C. M. Coopersmith. 2022. The RIPK3 Scaffold Regulates Lung Inflammation During Pseudomonas Aeruginosa Pneumonia. Am. J. Respir. Cell. Mol. Biol., in press. (PubMed)

Sarkar, L., L. Oko, S. Gupta, A. Bubak, B. Das, P. Gupta, A. Safiriyu, C. Singhal, U. Neogi, D. Bloom, A. Banerjee, R. Mahalingam, R. Cohrs, M. Koval, K. Schindler, D. Pal, M. Nagel, J. Das Sarma. 2022. Azadirachta indica A. Juss bark extract and its Nimbin isomers restrict beta-coronaviral infection and replication. Virology, 569:13-28. (PubMed)

Morgan, R., C. Manfredi, K. F. Easley, L. Watkins, W. R. Hunt, S. Goudy, E. J. Sorscher, M. Koval and S. A. Molina. 2022. A medium composition containing normal resting glucose that supports differentiation of primary human airway cells, Sci. Reports, 12:1540. (PubMed)

Hu, X., D. I. Walker, Y. Liang, M. R. Smith, M. L. Orr, B. D. Juran, C. Ma, K. Uppal, M. Koval, G. S. Martin, D. C. Neujahr, C. J. Marsit, Y.-M. Go, K. Pennell, G. W. Miller, K. N. Lazaridis, and D. P. Jones. 2021. A scalable workflow to characterize the human exposome. Nat Comm, 12:5575. doi: 10.1038/s41467-021-25840-9. (PubMed)

Cottrill, K. A., , V. D. Giacalone, C. Margaroli, R. J. Bridges, M. Koval, R. Tirouvanziam, and N. A. McCarty. 2021. Mechanistic analysis and significance of sphingomyelinase-mediated decreases in transepithelial CFTR currents in nHBEs. Physiol Rep. 9:e15023. (PubMed)

Cottrill, K.A., R. J. Peterson, C. F. Lewallen, M. Koval , R. J. Bridges, and N. A. McCarty. 2021. Sphingomyelinase decreases transepithelial anion secretion in airway epithelial cells in part by inhibiting CFTR-mediated apical conductance. Physiol Rep. 9:e14928. (PubMed)

Mandal, P., J. D. Lyons, E. M. Burd, M. Koval, E. S. Mocarski and C. M. Coopersmith. 2021. Integrated Evaluation of Lung Disease in Single Animals, PLOS One, 16: e0246270. (PubMed)

Cui, G., K. A. Cottrill, K. M. Strickland, S. A. Mashburn, M. Koval and N. McCarty. 2021. Alteration of membrane cholesterol content plays a key role in regulation of CFTR channel activity. Front Physiol, 12(705). doi: 10.3389/fphys.2021.652513. (PubMed)

Lynn, K.S., K. F. Easley, F. J. Martinez, R. C. Reed, B. Schlingmann, and M. Koval. 2021. Asymmetric distribution of dynamin-2 and beta-catenin relative to tight junction spikes in alveolar epithelial cells. Tissue Barriers, doi: 10.1080/21688370.2021.1929786. (PubMed)

Maier-Begandt, D., H. S. Comstra, S. A. Molina, N. Krüger, C. A. Ruddiman, Y. L. Chen, X. Chen, L. A. Biwer, S. R. Johnstone, A. W. Lohman, M. E. Good, L. J. DeLalio, K. Hong, H. M. Bacon, Z. Yan, S. K. Sonkusare., M. Koval, B. E. Isakson. 2021. A venous-specific purinergic signaling cascade initiated by Pannexin 1 regulates TNFalpha-induced increases in endothelial permeability, Sci Signal 14:eaba2940. (PubMed, Reprint, Full Text)

Schuler, B.A., A. C. Habermann, E. J. Plosa, C. J. Taylor, C. Jetter, N. M. Negretti, M. E. Kapp, J. T. Benjamin, P. Gulleman, D. S. Nichols, L. Z. Braunstein, A. Hackett, M. Koval, S. H. Guttentag, T. S. Blackwell, S. A. Webber, N. E. Banovich, J. A. Kropski, J. M. S. Sucre. 2021. Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium. J Clin Invest 131:e140766 doi: 10.1172/JCI140766. (PubMed)

Huang, X., X. Shi, M. E. Hansen, I. Setiady, C. L. Nemeth, A. Celli, B. Huang, T. Mauro, M. Koval, T. A. Desai. 2020. Nanotopography Enhances Dynamic Remodeling of Tight Junction Proteins through Cytosolic Liquid Complexes, ACS Nano 14:13192-13202. doi: 10.1021/acsnano.0c04866 (PubMed)

Bedi, B, K.-C. Lin, N. M. Maurice, Z. Yuan, K. Bijli, M. Koval, C. Hart, J. B. Goldberg, A. Stecenko, and R.T. Sadikot. 2020. UPR Modulation of Host Immunity by P. Aeruginosa in Cystic Fibrosis, Clin Sci (Lond.) CS20200066. doi: 10.1042/CS20200066. (PubMed)

Greeson, K., K. Fowler, P. Estave, S. Thompson, C. Wagner, R. Edenfield, K. Symosko, A. Steves, E. Marder, M. Terrell, H. Barton, M. Koval, M. Marcus and C. Easley. 2020. Detrimental effects of flame retardant, PBB153, exposure on sperm and future generations, Sci. Reports, 10(1):8567. (PubMed)

Yang, Y., L. Delalio, A. K Best, E. Maccal, I. Donnelly, A. M. Miller, M. McBride, X. H. Shu, M. Koval, B. E. Isakson and S. R. Johnstone. 2020. Endothelial pannexin 1 channels control inflammation by regulating intracellular calcium. J. Immunol., 204:2995-3007. (PubMed)

Maurice N.M., B. Bedi, Z. Yuan, J. B. Goldberg, M. Koval, C. M. Hart, R. T. Sadikot. 2019. Pseudomonas aeruginosa Induced Host Epithelial Cell Mitochondrial Dysfunction. Sci Rep. 2019 Aug 15;9(1):11929. (PubMed)

Smith P., L. A. Jeffers and M. Koval. 2019. Effects of different routes of endotoxin injury on barrier function in alcoholic lung syndrome. Alcohol, 80:81-89. (PubMed)

Moonwiriyakit, A., M. Koval and C. Muanprasat. 2019. Pharmacological stimulation of G-protein coupled receptor 40 alleviates cytokine-induced epithelial barrier disruption in airway epithelial Calu-3 cells. Int. Immunol., 73:353-361. (PubMed)

Vyas-Read, S., R. J. Vance, W. Wang, J. Colvocoresses-Dodds, L. A. Brown, and M. Koval. 2018. Hyperoxia induces paracellular leak and alters claudin expression by neonatal alveolar epithelial cells. Pediat. Pulmonol, 53:17-27. (PubMed)

Lorentz, C.A., Z. Liang, M. Meng, C.-W. Chen, B. P. Yoseph, E. R. Breed, R. Mittal, N. J. Klingensmith, A. B. Farris, E. M. Burd, M. Koval, M. L. Ford, C. M. Coopersmith. 2017. Myosin light chain kinase knockout improves gut barrier function and confers a survival advantage in polymicrobial sepsis, Mol. Med. 23:155-165. (PubMed)

Bedi, B., N. M. Maurice, V. T. Ciavatta, W. R. Tyor, K. S. Lynn, Z. Yuan, S. A. Molina, M. Joo, J. B. Goldberg, M. Koval, C. M. Hart and R. T. Sadikot. 2017. PPAR-gamma Agonists Attenuate Biofilm Formation by Pseudomonas aeruginosa, FASEB J., 31:3608-3621. (PubMed)

Stewart, T., W. T. Koval, S. A. Molina, S. M. Bock, J. W. Lillard, Jr., R. F. Ross, T. A. Desai and M. Koval. 2017. Calibrated flux measurements reveal a nanostructure-stimulated transcytotic pathway. Exp. Cell Res., 355:153-161. (PubMed)

Cornely, R.M., B. Schlingmann, W. S. Shepherd, J. D. Chandler, D. C. Neujahr, and M. Koval. 2017. Two common human CLDN5 alleles encode different open reading frames but produce one protein isoform, Annals of the New York Acad. Sci., 1397:119-129. (PubMed)

Molina, S.A., H. K. Moriarty, D. T. Infield, B. R. Imhoff, A. H. Kim, J. M. Hansen, W. R. Hunt, M. Koval, and N. A. McCarty. 2017. Insulin signaling via the PI3K/Akt pathway regulates airway glucose uptake and barrier function in a CFTR-dependent manner. Amer. J. Physiol. Lung Cell. Mol. Biol., 312:L688-L702. (PubMed)

Klingensmith, N. J., B. P. Yoseph, Z. Liang, J. D. Lyons, E. M. Burd, L. M. Margoles, M. Koval, M. L. Ford, C. M. Coopersmith. 2017. Epidermal growth factor improves intestinal integrity and survival in murine sepsis following chronic alcohol ingestion. Shock 47:184-192. (PubMed)

Schlingmann, B., C. E. Overgaard, S. A. Molina, K. S. Lynn, L. A. Mitchell, S. Dorsainvil White, A. L. Mattheyses, D. M. Guidot, C. T. Capaldo, M. Koval. 2016. Regulation of claudin / zonula occludens-1 complexes by hetero-claudin interactions. Nat. Commun., 7:12276. (PubMed)

Schadzek, P., B. Schlingmann, F. Schaarschmidt, J. Lindner, M. Koval, A. Heisterkamp, M. Preller, A. Ngezahayo. Data of the molecular dynamics simulations of mutations in the human connexin46 docking interface. 2016. Data in Brief, 7:93-99. (PubMed)

Schadzek, P., B. Schlingmann, F. Schaarschmidt, J. Lindner, M. Koval, A. Heisterkamp, M. Preller, A. Ngezahayo. The cataract related mutation N188T in human connexin46 (hCx46) revealed a critical role for residue N188 in the docking process of gap junction channels. 2016. BBA Biomembranes, 1858:57-66. (PubMed)

He, P., L. Zhao, L. Zhu, E. J. Weinman, R. De Giorgio, M. Koval, S. Srinivasan, and C. C. Yun. Coordinated assembly of NHE3, IRBIT, NHERF1, and ezrin ameliorates fluid malabsorption in diabetes. 2015. J. Clin. Invest., 125:3519-3531. (PubMed)

Molina, S.A., B. Stauffer, H. K. Moriarty, A. Kim, N. A. McCarty, and M. Koval. 2015. Junctional abnormalities in human airway epithelial cells expressing F508del CFTR. Amer. J. Physiol. Lung Cell. Mol. Biol., 309:L475-87. (PubMed)

Overgaard, C.E., B. Schlingmann, S. Dorsainvil White, C. Ward., X. Fan, S. Swarnakar, L. A. Brown, D. M. Guidot and M. Koval. 2015. The relative balance of GM-CSF and TGFbeta1 regulates lung epithelial barrier function. Amer. J. Physiol. Lung Cell. Mol. Biol., 308:L1212-23. (PubMed)

Farkas, A. E., R. Hilgarth, C. T. Capaldo, C. Gerner-Smidt, D. R. Powell, P. M. Vertino, M. Koval, C. A. Parkos, A. Nusrat. 2015. HNF4alpha regulates claudin-7 protein expression during intestinal epithelial differentiation. Amer. J. Pathol., 185:2206-2218. (PubMed)

Ward, C., B. Schlingmann, A. A. Stecenko, D. M. Guidot, M. Koval. 2015. NF-kB inhibitors impair lung epithelial tight junctions in the absence of inflammation. Tissue Barriers, 3:e982424. (PubMed)

Walsh, L., J. Ryu, S. Bock, M. Koval, T. Mauro, R. Ross and T. Desai. 2015. Nanotopography facilitates in vivo transdermal delivery of high molecular weight therapeutics through an integrin-dependent mechanism. Nano Letters, 15:2434-2441. (PubMed)

Kopanic, J. L., B. Schlingmann, M. Koval, A. F. Lau, P. L Sorgen, V. F Su. 2015. Degradation of gap junction connexins is regulated by the interaction with Cx43-interacting protein of 75 kDa (CIP75). Biochem. J., 466:571-585. (PubMed)

Mitchell, L. A., C. Ward, M. Kwon, P. O. Mitchell, D. A. Quintero, A. Nusrat, C. A. Parkos and M. Koval. 2015. Junctional Adhesion Molecule A promotes epithelial tight junction assembly to augment lung barrier function. Amer. J. Pathol., 85:372-386. (PubMed)

Capaldo, C.T., A. E. Farkas, R. S. Hilgarth, S. M. Krug, M. F. Wolf, J. K. Benedik, M. Fromm, M. Koval, C. A. Parkos, A. Nusrat. 2014. Proinflammatory cytokine-induced Tight Junction remodeling through dynamic self-assembly of claudins. Mol Biol Cell. 25:2710-2719. (PubMed)

Stahley, S.N., M. Saito, V. Faundez, M. Koval, A. L. Mattheyses, A. P. Kowalczyk. 2014. Desmosome assembly and disassembly are membrane raft-dependent. PLoS One. 9:e87809. (PubMed)

Hunt, W. R., S. M. Zughaier, D. E. Guentert, M. A. Shenep, M. Koval, N. A. McCarty, and J. M. Hansen. 2014. Hyperglycemia impedes lung bacterial clearance in a murine model of cystic fibrosis-related diabetes. Amer. J. Physiol. Lung Cell. Mol. Biol. 306:L43-49. (PubMed)

X. Fan, X. B. S. Staitieh , J. S. Jensen , K. J. Mould , J. A. Greenberg , P.C. Joshi, M. Koval and D. M. Guidot. 2013. Activating the Nrf2-mediated antioxidant response element restores barrier function in the alveolar epithelium of HIV-1 transgenic rats. Amer. J. Physiol. Lung Cell. Mol. Biol., 305:L267-277. (PubMed)

Yoseph, B. Z. Liang, E. Breed, K. McConnell, D. M. Guidot, M. Koval and C. M. Coopersmith. 2013. Chronic Alcohol Consumption Increases Mortality in Sepsis, PLoS ONE 8:e62792. (PubMed)

Kam K., L. A. Walsh, S. M. Bock, K.E. Fischer, M. Koval, R. Ross, T. A. Desai. 2013. Nanostructure-Mediated Transport of Biologics across Epithelial Tissue: Enhancing Permeability via Nanotopography. Nano Lett. 13:164-171. (PubMed)

Johnston, S.R., B.M. Kroncke, A.C. Straub, A.K. Best, C.A. Dunn, L. A. Mitchell, Y. Peskova, R.K. Nakemoto, M. Koval, C.W. Lo, P.D. Lampe, L. Columbus and B. E. Isakson. 2012. MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation. Circ Res., 111:201-211. (PubMed)

Smith, T.D., A. Mohankumar, P. J. Minogue, E. C. Beyer, V. M. Berthoud, M. Koval. 2012. Cytoplasmic amino acids within the membrane interface region influence connexin oligomerization, J. Membr. Biol., 245:221-230. (PubMed)

Goodson, P., A. Kumar, K. Kundu, N. Murthy, M. Koval, and M. N. Helms. 2012. NADPH oxidase regulates alveolar epithelial sodium channel (ENaC) activity and lung fluid balance in vivo via O2- signaling. Amer. J. Physiol. Lung Cell. Mol. Biol., 302:L410-419. (PubMed)

Mitchell, L. A., C. E. Overgaard, C. Ward, S. S. Margulies and M. Koval. 2011. Differential effects of claudin-3 and claudin-4 on alveolar epithelial barrier function, Amer. J. Physiol. Lung Cell. Mol. Biol., 301:L40-49. (PubMed)

Koval, M., M. Billaud, A. C. Straub, A. Zarbock, B. R. Duling, B. E. Isakson, 2011. Spontaneous lung dysfunction and fibrosis in mice lacking connexin40 and endothelial cell connexin43, Amer. J. Path., 178:2536-2546. (PubMed)

Fan, X., P. C. Joshi, M. Koval and D. M. Guidot. 2011. Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats, Alcohol. Clin. Exp. Res., 35:1866-1875. (PubMed)

Su, V., R. Nakagawa, M. Koval, A.F. Lau. 2010. Ubiquitin-independent proteasomal degradation of ER-localized connexin43 mediated by CIP75. J Biol Chem. 285:40979-40990.(PubMed)

Go Y.M., H. Park, M. Koval, M. Orr, M. Reed, Y. Liang, D. Smith, J. Pohl, D.P. Jones. 2010. A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potential. Free Radic Biol Med. 48:275-283. (PubMed)

Koval, M., C. Ward, M.K. Findley, S. Roser-Page, M. N. Helms, J. Roman. 2010. Extracellular matrix influences alveolar epithelial claudin expression and barrier function, Amer. J. Respir. Cell Mol. Biol., 175:1799-1801. (PubMed)

Das, S., J. Das Sarma, J. D. Ritzenthaler, T. Smith, J. Maza, B. E. Kaplan, L. A. Cunningham, L. Suaud, R. C. Rubenstein, M. Koval. 2009. Regulation of connexin43 oligomerization and trafficking by ERp29, Mol. Biol. Cell, 20:2593-2604. (PubMed)

Lassiter, C., X. Fan, P. C. Joshi, B. A. Jacob, R. L. Sutliff, D. P. Jones, M. Koval and D. M. Guidot. 2009. HIV-1 transgene expression in rats causes oxidant stress and alveolar epithelial barrier dysfunction. AIDS Research and Therapy, 6:1. (PubMed)

Das Sarma, J., B. E. Kaplan, D. Willemsen and M. Koval. 2008. Identification of rab20 as a potential regulator of connexin43 trafficking. Cell Commun. and Adhesion, 15:65-74. (PubMed)

Das Sarma, J., K. Iacono, L. Gard, L. Kenyon, M. Koval and S. R. Weiss. 2008. Demyelinating and non demyelinating strains of mouse hepatitis virus differ in their neural cell tropism. J. Virol. 82:5519-5526 (PubMed)

Mrsny, R. J., G. T. Brown, , K. Gerner-Smidt, A. G. Buret, J. B. Meddings, C. Quan, M. Koval and A. Nusrat. 2008. A key claudin extracellular loop domain is critical for epithelial barrier integrity. Amer. J. Path., 172:905-915 (PubMed)

Garnacho, C., V. Shuvaev, A. Thomas, L. MacKenna, M. Koval, S. Albelda, S. Muro and V. Muzykantov. 2008. Activation and recruitment of RhoA induced by anti-PECAM nanocarriers during CAM-mediated endocytosis: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1. Blood, 111:3024-3033 (PubMed)

Laukoettor, M. G., P. Nava, W. Lee, C. Capaldo, E. Severson, B. Babbin, I. Williams, M. Koval, J. Campbell, T. Dermody, A. Nusrat, C. A. Parkos. 2007. JAM-A regulates mucosal permeability, claudin expression and intestinal inflammation in vivo. J. Exp. Med., 204:3067-3076 (PubMed)

Daugherty, B.L., C. Ward, T. Smith, J. D. Ritzenthaler, M. Koval. 2007. Regulation of heterotypic claudin compatibility, J. Biol. Chem. 282:30005-30013 (PubMed)

Fernandez, A. L., M. Koval, X. Fan and D. M. Guidot. 2007. Chronic alcohol ingestion alters claudin expression in the alveolar epithelium of rats, Alcohol, 41:371-379 (PubMed)

Blanchard-Fillion, B., M. Polydoro, D. Spielberg, Z. Wang, S. L. Hazen, M. Koval, and H. Ischiropoulos. 2006. Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells, J. Neurosci., 26:6124-6130 (PubMed)

Muro S., M. Mateescu, C. Gajewski, M. Robinson, V. R. Muzykantov, M. Koval. 2006. Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na+/H+ Exchanger (NHE) proteins. Am J Physiol Lung Cell Mol Physiol. 290:L809-817 (PubMed).

Das Sarma, J., S. Das and M. Koval. 2005. Regulation of connexin43 oligomerization is saturable. Cell Commun. and Adhesion 12:237-247 (PubMed).

Laing J.G., M. Koval, and T. H. Steinberg. 2005. Association with ZO-1 Correlates with Plasma Membrane Partitioning in Truncated Connexin45 Mutants. J Membr. Biol. 207:45-53 (PubMed).

Fries D.M., R. Lightfoot, M. Koval and H. Ischiropoulos. 2005. Autologous Apoptotic Cell Engulfment Stimulates Chemokine Secretion by Vascular Smooth Muscle Cells. Am. J. Pathol. 167:345-353 (PubMed).

Patel A.S., D. Reigada, C. H. Mitchell, S. R. Bates, S. S. Margulies and M. Koval. 2005. Paracrine stimulation of surfactant secretion by extracellular ATP in response to mechanical deformation. Am J Physiol Lung Cell Mol Physiol. 289:L489-496 (PubMed).

Yoshino, A., S. R. Setty, C. Poynton, E. L. Whiteman, A. Saint-Pol, C. G. Burd, L. Johannes, E. L. Holzbaur, M. Koval, J. M. McCaffery and M. S. Marks. 2005 tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre. J. Cell Sci. 118:2279-2293.(PubMed).

Maza, J., J. Das Sarma and M. Koval. 2005. Defining a minimal motif required to prevent connexin oligomerization in the endoplasmic reticulum. J Biol Chem., 280:21115-21121 (PubMed).

Muro, S., C. Gajewski, M. Koval and V. R. Muzykantov. 2005. ICAM-1 recycling in endothelial cells: a novel pathway for sustained intracellular delivery and prolonged effects of drugs, Blood. 105:650-658.(PubMed).

Daugherty, B., M. Mateescu, A. S. Patel, K. Wade, S. Kimura, L. W. Gonzales, P. L. Ballard and M. Koval. 2004. Developmental regulation of claudin localization by fetal alveolar epithelial cells, Amer. J. Physiol. Lung Cell. Mol. Biol., 287:L1266-1273 (PubMed).

Lin, G.C., J.K. Rurangirwa, M. Koval, and T.H. Steinberg. 2004. Gap junctional communication modulates agonist-induced calcium oscillations in transfected HeLa cells. J Cell Sci. 117:881-7.(PubMed).

Maza, J., M. Mateescu, J.D. Sarma, and M. Koval. 2003. Differential oligomerization of endoplasmic reticulum-retained connexin43/connexin32 chimeras. Cell Commun Adhes. 10:319-22.(PubMed).

Muro, S., X. Cui, C. Gajewski, J.C. Murciano, V.R. Muzykantov, and M. Koval. 2003. Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress. Am J Physiol Cell Physiol. 285:C1339-47.(PubMed).

Wang, F., B. Daugherty, L. L. Keise, Z. Wei, J. P. Foley, R. C. Savani, and M. Koval. 2003. Heterogeneous claudin expression by alveolar epithelial cells. 2003. Amer. J. Respir. Cell Mol. Biol., 29:62-70. (PubMed)

Muro, S., R. Wiewrodt, L. Koniaris, A. P. Thomas, S. M. Albelda, V. Muzykantov and M. Koval. A novel endocytic pathway induced by clustering endothelial ICAM-1 or PECAM-1. 2003. J. Cell Sci., 116:1599-1609 (PubMed)

Das Sarma, J., E. Scheen, S. Seo, M. Koval and S. R. Weiss. 2002. Selection of a recombinant murine coronaviruses with efficient and stable expression of Enhanced Green Fluorescent Protein. J. Neurovirol. 8:381-91. (PubMed)

Mulugeta, S., J. Gray, K. Notarfrancesco, L. W. Gonzales, M. Koval, S. I. Feinstein, P. L. Ballard, A. B. Fisher and H. Shuman. 2002. Identification of lbm180, a Lamellar Body Limiting Membrane Protein of Alveolar Type II Cells, as the ABC Transporter Protein, ABCA3. J. Biol. Chem.,277:22147-55. (PubMed)

Das Sarma, J. F. Wang, and M. Koval. 2002. Targeted gap junction protein constructs reveal connexin-specific differences in oligomerization. J. Biol. Chem., 277:20911-20918. (PubMed)

Wiewrodt, R., A. P. Thomas, L. Cipelletti, D. A. Weitz, S. M. Albelda, M. Koval and V. Muzykantov. 2002. Size-dependent intracellular immunotargeting into endothelial cells via a surface adhesion molecule, PECAM-1. Blood, 99:912-922 (PubMed)

Das Sarma, J., C. W. Lo and M. Koval. 2001. Cx43/beta-gal inhibits Cx43 transport in the Golgi Apparatus. Cell Commun. Adhes., 8:249-252. (PubMed)

Das Sarma, J., R. I. Meyer, F. Wang, V. Abraham, C. W. Lo and M. Koval. 2001. Multimeric connexin interactions prior to the trans Golgi apparatus. J. Cell Sci., 114:4013-24 (PubMed)

Abraham, V., M. L. Chou, P. George, P. Pooler, A. Zaman, R. C. Savani and M. Koval. 2001. Heterocellular communication between alveolar epithelial cells. Amer. J. Phys. Lung Cell and Mol. Biol., 280:L1085-L1093. (PubMed)

Laing, J. G., R. N. Manley-Markowski, M. Koval, R. Civitelli, and T. H. Steinberg. 2001. Connexin45 interacts with Zonula Occludens-1 and Connexin43 in Osteoblastic Cells. J. Biol. Chem, 276:23051-23055. (PubMed)

Abraham, V., M. Chou, K. DeBolt and M. Koval 1999. Phenotypic control of gap junctional communication by alveolar epithelial cells. Amer. J. Phys. Lung Cell and Mol. Biol. 276:L825-834. (PubMed)

Lecanda, F., D. A. Towler, K. Ziambaras, S.-L. Cheng, M. Koval, T. H. Steinberg & R, Civitelli. 1998. Gap junctional communication modulates gene expression in osteoblastic cells. Mol. Biol. Cell, 9:2249-2258. (PubMed)

Koval, M., K. Preiter, C. Adles, P. D. Stahl, and T. H. Steinberg. 1998. Size of IgG-opsonized particles determines macrophage response during internalization. Exp. Cell Res., 242:265-273. (PubMed)

Roach, T., S. Slater, M. Koval, L. White, E. Cahir-McFarland, M. Okamura, M. Thomas, and E. Brown. 1997. CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion. Curr. Biol. 7:408-417. (PubMed)

Koval, M., E. Hick, J. Harley, and T. H. Steinberg. 1997. Connexin46 is retained as monomers in a trans-Golgi compartment of osteoblastic cells. J. Cell Biol., 137:847-857. (PubMed)

Koval, M., S. T. Geist, E. M. Westphale, A. E. Kemendy, R. Civitelli, E. C. Beyer and T. H. Steinberg. 1995. Transfected connexin45 alters gap junction permeability in cells expressing endogenous connexin43. J. Cell Biol., 130:987-995. (PubMed)

Treves, S., F. Larini, P. Menegazzi, T. H. Steinberg, M. Koval, B. Vilsen, and F. Zorzato. 1994. Alteration of intracellular Ca+2 transients in COS-7 cells transfected with cDNA encoding skeletal muscle ryanodine receptor carrying a mutation associated with malignant hyperthermia. Biochem. J., 301:661-5. (PubMed)

Diaz, R., M. I. Colombo, M. Koval, L. Mayorga, and P. Stahl. 1991. Endosomal density shift is related to a decrease in fusion capacity. Eur. J. Cell Biol. 56:223-232. (PubMed)

Koval, M., and R. E. Pagano. 1990. Sorting of an internalized plasma membrane lipid between recycling and degradative pathways in normal and Niemann-Pick, type A fibroblasts. J. Cell Biol. 111:429-442. (PubMed)

Palmer, R. E., M. Koval, and D. Koshland. 1989. The dynamics of chromosome movement in the budding yeast Saccharomyces cerevisiae. J. Cell Biol. 109:3355-3366. (PubMed)

Koval, M., and R. E. Pagano. 1989. Lipid recycling between the plasma membrane and intracellular compartments: Transport and metabolism of fluorescent sphingomyelin analogues in cultured fibroblasts. J. Cell Biol. 108:2169-2181. (PubMed)

Schwartz, D. C., and M. Koval. 1989. Conformational dynamics of individual DNA molecules during gel electrophoresis. Nature 338:520-522. (PubMed)

Parry, G., E. Y.-H. Lee, D. Farson, M. Koval, and M. J. Bissell. 1985. Collagenous substrata regulate the nature and distribution of glycosaminoglycans produced by differentiated cultures of mouse mammary epithelial cells. Exp. Cell Res. 156:487-499. (PubMed)

Research Articles | PubMed link | Google Scholar Profile

Reviews and Chapters

Khair, S., L. A. Brenner, M. Koval, D. Samuelson, J. A. Cucinello-Regland, P. Anton, M. R. Piano, L. Simon, K. Crotty, F. Sharieh, J. B. Travers, V. Singh, A. Cannon, A. Kim, R. L. McCullough, T. A. Wyatt, R. H. McMahan, M. A. Choudhry, E. J. Kovacs. 2022. New insights into the mechanism of alcohol-mediated organ damage via its impact on immunity, metabolism, and repair pathways: A Summary of the 2021 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 103:1-7. doi: 10.1016/j.alcohol.2022.05.004. (PubMed)

Molina, S. A., D. Maier-Begandt, B. E. Isakson and M. Koval. 2022. Electrophysiological Measurements of Isolated Blood Vessels. Bio-protocol 12(6): e4359. DOI: 10.21769/BioProtoc.4359. PMCID: PMC8983162. (PubMed)

Koval, M. 2022. Roles for claudins in regulating lung barriers and function. in Tight Junctions. Lorenza González-Mariscal, editor. Springer International, 217-226.

King, D. R., M. W. Sedovy, X. Leng, J. Xue, S. Lamouille, M. Koval, B.E. Isakson and S. R. Johnstone 2021. Mechanisms of Connexin Regulating Peptides. Int J Mol Sci, 22:10186. (PubMed)

Koval, M. 2022. Connexins. in Encyclopedia of Respiratory Medicine, Second edition. Sam Janes, editor. Elsevier, Academic Press, 606-611.

King, D. R., M. W. Sedovy, X. Leng, J. Xue, S. Lamouille, M. Koval, B.E. Isakson and S. R. Johnstone 2021. Mechanisms of Connexin Regulating Peptides. Int J Mol Sci, 22:10186. (PubMed)

Peterson, R.J. and M. Koval. 2021 Above the Matrix: functional roles for apically localized integrins, Front. Cell Dev. Biol. 9:699407. doi: 10.3389/fcell.2021.699407. (PubMed)

Koval M., A. Cwiek, T. Carr, M. E. Good, A. W. Lohman and B. E. Isakson. 2021. Pannexin 1 as a driver of inflammation and ischemia reperfusion injury, Purinergic Signaling, 17:521-531. (PubMed)

Smith, P., L. A. Jeffers and M. Koval. 2021. Measurement of lung vessel and epithelial permeability in vivo with Evans Blue. Methods Mol. Biol. 2367:137-148. (PubMed)

Swayne, L. A., S. R. Johnstone, C. S. Ng, J. C. Sanchez-Arias, M. E. Good, S. Penuela, A. W. Lohman, V. E. Laubach, M. Koval and B. E. Isakson. 2020. Consideration of Pannexin 1 channels in COVID-19 pathology and treatment. Amer. J. Physiol. Lung Cell and Mol. Biol., 319:L121-L125. (PubMed)

Lynn, K.S., R. J. Peterson and M. Koval. 2020. Ruffles and Spikes: Control of tight junction morphology and permeability by claudins. Biochim Biophys Acta Biomembr, 1862, 9: 183339. (peer reviewed). (PubMed)

Smith, P., M. Koval and J. M. Levy. 2020. Mucosal Barrier Defects: What Have We Learned from Atopic Dermatitis, Asthma, and Allergic Rhinitis?. Curr Otorhinolaryngol Rep, doi:10.1007/s40136-020-00267-w.

Aasen, T., S. Johnstone, L. Vidal-Brime, K. S. Lynn and M. Koval. 2018. Connexins: synthesis, post-translational modifications and trafficking in health and disease. Int. J. Mol. Sci., 19:1296. (peer reviewed).(PubMed)

Koval, M., and V. K. Sidhaye. 2017. Introduction: The Lung Epithelium in Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease, Venkataramana K. Sidhaye and Michael Koval, editors, Academic Press, pp xiii-xviii

Koval, M. 2017. Junctional Interplay in Lung Epithelial Barrier Function in Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease, Venkataramana K. Sidhaye and Michael Koval, editors, Academic Press, pp 1-20.

Koval, M., S. A. Molina and B. Schlingmann. 2016. Use of Super-resolution Immunofluorescence Microscopy to Analyze Tight Junction Protein Interactions in situ. Microscopy and Microanalysis, 22 (S3), 1014-1015.

Koval, M. 2016. Structure and function of epithelial and endothelial barriers. in Drug Delivery Across Physiological Barriers, Silvia Muro, editor. Pan Stanford Publishing, 3-39.

Liu,F., M. Koval, S. Ranganathan, S. Fanayan, W.S. Hancock, E. K.Lundberg, R.C. Beavis, L. Lane, P. Duek, L. McQuade, N. L. Kelleher and M. S. Baker. 2016. A systems proteomics view of the endogenous human claudin protein family. J Proteome Res., 15:339-59 (peer reviewed).(PubMed)

Koval, M. 2015. The expanding diversity of roles for claudins. Seminars in Cell Dev. Biol., 42:1-2. (PubMed)

Schlingmann, B., S. A. Molina and M. Koval. 2015. Claudins: gatekeepers of lung epithelial function. Seminars in Cell Dev. Biol., 42:47-57. (PubMed)

Schlingmann, B. L., C. Ward, S. A. Molina, C. E. Overgaard, D. M. Guidot and M. Koval. 2015. Alveolar Barrier Function in Alcoholic Lung Syndrome is Impaired by Tight Junction Destabilization. Annals of the Amer. Thoracic Soc., 12 Suppl 1:S75-6. (PubMed)

Koval M., B. E. Isakson, R. G. Gourdie. 2014. Connexins, pannexins and innexins: protein cousins with overlapping functions. FEBS Lett. 588:1185. (PubMed)

Koval M., S. A. Molina, J. M. Burt. 2014. Mix and match: investigating heteromeric and heterotypic gap junction channels in model systems and native tissues. FEBS Lett. 588:1193-1204. (PubMed)

Molina, S. A. and M. Koval. 2013. Alcohol and the Alveolar Epithelium. in Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach, David M. Guidot and Ashish J. Mehta, editors. Springer, pp 83-102.

Koval, M. 2013. Differential pathways of claudin oligomerization and integration into tight junctions. Tissue Barriers, 2013; 1:e24518 (PubMed)

Chanson, M. and M. Koval. 2013. Connexins in lung function and inflammation. in Connexin Cell Communication Channels: Roles in the Immune System and Immunopathology, W. Howard Evans, Ernesto Oviedo-Orta and Brenda Kwak, editors, Taylor & Francis, pp 137-156.

Koval, M. 2013. Drowning out communication. Editorial Focus on: The human Cx26-D50A and Cx26-A88V mutations causing Keratitis-Ichthyosis-Deafness syndrome display increased hemichannel activity. (PubMed)

Koval, M. 2013. Claudin Heterogeneity and Control of Lung Tight Junctions, Annu. Rev. Physiol., 75:551-567. (PubMed)

Overgaard, C.E., L.A. Mitchell, and M. Koval. 2012. Roles for claudins in alveolar epithelial barrier function. Annals of the New York Acad. Sci., 1257:167-174. (PubMed)

Overgaard, C. E., B. L. Daugherty, L. A. Mitchell and M. Koval. 2011. Claudins: Control of Barrier Function and Regulation in Response to Oxidant Stress, Antioxid. Redox. Signal., 15:1179-1193. (PubMed)

Ward, C. and M. Koval. 2011. Biochemical analysis of claudin binding compatibility. Methods Mol. Biology. 762:13-26.(PubMed)

Mitchell, L. A. and M. Koval. 2010. Specificity of Interaction between Clostridium perfringens Enterotoxin and Claudin-Family Tight Junction Proteins. Toxins (Basel). 2:1595-1611. (PubMed)

Koval, M. 2010. Keratinocyte growth factor improves alveolar barrier function: keeping claudins in line. Am J Physiol Lung Cell Mol Physiol. 299:L721-723 (full article) (PubMed)

Koval, M. 2009. Tight junctions, but not too tight: fine control of lung permeability by claudins. Am J Physiol Lung Cell Mol Physiol., 297:L217-218 (full article) (PubMed)

Eaton, D.C., M. N. Helms, M. Koval, H. F. Bao, and L. Jain. 2009. The Contribution of Epithelial Sodium Channels to Alveolar Function in Health and Disease. Ann. Rev. Physiol., 71:403-23 (PubMed)

Findley, M.K. and M. Koval. 2009. Regulation and Roles for Claudin-Family Tight Junction Proteins. IUBMB Life, 61:431-437 (PubMed)

Johnson, L. N. and M. Koval. 2009. Crosstalk between injury-stimulated signaling, oxidant stress and pulmonary gap junctional communication. Antioxid. Redox. Signal., 11:355-367 (PubMed)

Koval, M., X. Fan, A. L. Fernandez, L. N. Johnson, P. C. Joshi, D. M. Guidot. 2008. Effects of alcohol and GM-CSF on alveolar tight junctions. Proc. Amer. Thoracic Soc., 5:368-369. - Proceedings of the Aspen Lung Conference

Koval, M. 2008. Gap Junctions - Connexin Functions and Roles in Human Disease. in Cell Junctions: Adhesion, Development And Disease, Susan E. LaFlamme and Andrew Kowalczyk, editors, Wiley-VCH. pp 197-216.

Bhattacharya, J., M. Koval and W. Kuebler. 2008. The Pulmonary Circulation. in Handbook of Physiology, Microcirculation, second edition. Ronald F. Tuma, Walter N. Duran and Klaus Ley, editors, Academic Press, pp 712-734.

Koval, M. 2006. Claudins: key pieces in the tight junction puzzle. Cell Commun. Adhesion, 13:127-138 (PubMed)

Koval, M. 2006. Pathways and control of connexin oligomerization. Trends Cell Biol. 16:159-166.(PubMed)

Dzubila, T., S. Muro, V. R. Muzykantov and M. Koval. 2006. Nanoscale Anti-Oxidant Therapeutics. in Oxidative Stress, Disease and Cancer, Keshav K. Singh, editor. Imperial College Press, London, pp 1023-1044.

Koval M. 2006. Connexins, tissue expression. in Encyclopedia of Respiratory Medicine, G. J. Laurent and S. D. Shapiro, editors. Elsevier, San Diego, CA., 558-560.

Koval, M. and J. Bhattacharya. 2005. Vascular Gap Junctions. in Encyclopedia of the Microvasculature, David Shepro, editor. Elsevier, San Diego, CA.

Boitano, S., Z. Safdar, D.G. Welsh,J. Bhattacharya and M. Koval. 2004. EB meeting report: Cell-cell interactions between lung cells. Amer. J. Physiol. Lung Cell and Mol. Biol., 287:L455-9 (PubMed)

Muro, S., M. Koval and V. R. Muzykantov. 2004. Mechanisms for drug targeting to vascular endothelium. Curr. Vasc. Pharm., Curr. Vasc. Pharm. 2:281-299.(PubMed)

Koval, M. 2002. Sharing signals: connecting lung epithelial cells with gap junctions. Amer. J. Physiol. Lung Cell and Mol. Biol. 283:L875-93.(PubMed)

Abraham, V., K. DeBolt, R. Savani and M. Koval. 1999. Regulation of gap junction proteins by alveolar epithelial cells in response to injury. Chest, 35S. - Proceedings of the Aspen Lung Conference (PubMed)

Koval, M., E. Hick, J. E. Harley and T. H. Steinberg. 1998. Cell-specific differences in transport and assembly of Connexin46. in Gap Junctions, R. Werner, ed. ISO Press, Amsterdam. 102-106.

Koval, M., A. H. Futerman and R. E. Pagano. 1995. Sphingomyelin synthesis in endosomes? Trends. Cell Biol., 5:148-149.

Koval, M. 1993. Plasma membrane lipid transport in cultured cells: Studies using lipid analogs and model systems. Adv. in Cell and Molec. Biol. of Membr. 1:199-224.

Lenhard, J. M., M. I. Colombo, M. Koval, G. Li, L. S. Mayorga, and P. D. Stahl. 1993. Identification of proteins involved in endosome fusion: Implications for toxin activity. in Botulinium and Tetanus Neurotoxins: Neurotransmission and Biomedical Aspects. B. R. Das Gupta, ed. Plenum Publishing, N.Y. 120-132.

Koval, M., and R. E. Pagano. 1991. Intracellular transport and metabolism of sphingomyelin. Biochim. Biophys. Acta 1082:113-125 (PubMed)

Shero, J. H., M. Koval, F. Spencer, R. Palmer, P. Hieter, and D. Koshland. 1990. Analysis of Chromosome segregation in S. cerevisiae. Meth. Enz. 194:749-773. (PubMed)

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